Using low dose heparin for prevention of sickle cell

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Old 03-15-2004, 10:45 AM
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Using low dose heparin for prevention of sickle cell



I just had a physician ask me about using low dose heparin for a patient to prevent their sickle cell crisis from being so frequent. We have talked about hydroxyurea for this but not low dose heparin. Has anyone heard of this and if so could you elaborate?
Thanks,
Elora Thorpe RN
Coordinator
St. Luke's Hospital of Kansas City
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Elora Thorpe RN BSN
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Blood Conservation Program
St. Luke's Hospital of Kansas City
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Old 04-13-2009, 08:32 PM
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Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin

Preliminary trial of minidose heparin prophylaxis ...[East Afr Med J. 1989] - PubMed Result
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Old 04-14-2009, 01:04 PM
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in contrast possibly see

Method for treating sickle cell disease and sickle cell disease sequalae invention

If heparin helps improve quality of life, then go with that. The above link mentions that the effect unfortunately does not occur with low molecular weight heparins!
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