NoBlood

Jan B. Wade · #1 (**permalink**) 09-03-2005, 04:19 AM

Blood transfusion - The Silent Epidemic

http://www.jw-media.org/vnr/2253636331/734353.htm

mkribs · #2 (**permalink**) 06-28-2006, 04:15 PM

Please help me locate the information regarding the oxygen carrying capacity in transfused RBC's. As a JW (and nurse) I am doing a research assignment for a class in relation to bloodless surgery. I believe a nursing instructor once told me that transfusions are simply volume replacement because the 02 capacity is not available for 24-48 hours. Is this correct?
Marcy

rjbsec · #3 (**permalink**) 07-09-2006, 03:33 AM

Due to the loss of 2,3 DPG which allows the blood to release 02, the 02 carrying capacity of stored blood is around 50% after 24 hours, whereas salvaged blood maintains almost full 02 carrying capacity - some references available:-

Quote:

Blood in cold storage contains glucose as a potential substrate for ATP production, but the glycolytic enzymes do not work well in the cold. Remember, DPG is produced as a byproduct of glycolysis. Thus, DPG levels decrease in refrigerated (stored) blood. Thus, if refrigerated whole blood is stored for too long, it becomes less efficient at O2 unloading, because it contains less DPG!

DPG decreases so much by the time the blood is 10 days old that the Hb affinity for O2 is actually increased such that less O2 is released from Hb which has been refrigerated for 10 days. For this reason, refrigerated blood is not normally stored beyond 21 days; if refrigerated blood older than 21 days is transfused, it picks up O2 at the lung but will not release the O2 at the tissues. Transfusion of blood older than 21 days actually impairs O2 transfer to the tissues. When older refrigerated blood is returned to the body, the levels of DPG present in the blood will gradually increase, but the initial decline in O2 carrying capacity following transfusion should be considered potentially dangerous.

( THE HEMOGLOBIN PAGE )

Entrez PubMed

Chemical changes in stored blood, with observations on the effects of adenosine

2,3-diphosphoglycerate test

roberto martine · #4 (**permalink**) 07-10-2006, 05:18 PM

Quote:

Originally Posted by mkribs

Please help me locate the information regarding the oxygen carrying capacity in transfused RBC's. As a JW (and nurse) I am doing a research assignment for a class in relation to bloodless surgery. I believe a nursing instructor once told me that transfusions are simply volume replacement because the 02 capacity is not available for 24-48 hours. Is this correct?
Marcy

hello my name are roberto martinez iam an hyperbaric technitian i have 8 years of experience on those years i see many patient get well
they came with very low hemoglobine, and after 20-30 therapies ,hemoglobine leves come to the normal .
in hyperbaric medicine we dont use red cells to transport oxigen.. we use plasma
it is a very good estudie dr ite borema treat severe blood loose with hyperbaric chamber
if you want more info please e mail
i work in an hyperbaric center in juarez mex
porres34@hotmail.com

mkribs · #5 (**permalink**) 07-24-2006, 02:57 PM

I enjoyed the clip, Jan. Given the amount of researched information regarding the hazards of blood, I am utterly amazed that the FDA even allows its use.
My son just had a complex 13 1/2 hour spinal surgery (by a cooperative and skilled surgeon) without the use of blood here in Northern, CA. He was discharged home on day nine without complication. It took thorough interviews of five separate specialists before deciding who to choose. The point is, listen to direction, thoroughly prepare for planned procedures, be clear with expectations and fill out the DPA.
Thanks to all of you for the information.
Marcy