South Med J 2003 Jan;96(1):12-6 Related Articles, Links
Preliminary experience with the use of recombinant factor VIIa to treat coagulation disturbances in pediatric patients.
Tobias JD, Groeper K, Berkenbosch JW.
Department of Anesthesiology, University of Missouri, Columbia, MO 65212, USA.
Tobiasj@health.missouri.edu
OBJECTIVE: This study evaluates the efficacy of recombinant factor VII (rVIIa) in the treatment of coagulation dysfunction in pediatric patients. METHODS: We retrospectively reviewed the records of pediatric patients who received rVIIa in the intensive care unit or operating room for treatment of coagulopathy. Case series in the literature were also reviewed. RESULTS: Ten patients, ranging in age from 3 months to 19 years, received 22 doses of rVIIa. Seven of the 10 patients had received fresh frozen plasma and cryoprecipitate before the administration of rVIIa without effect. All 10 patients had a fibrinogen level above 100 mg/dl and platelet count above 100,000/mm3 at the time of rVIla administration. After rVIIa administration, there were significant decreases in prothrombin time, international normalized ratio, and partial thromboplastin time. No adverse effects were noted. CONCLUSION: Recombinant factor VIIa can be used to effectively reverse coagulation disturbances in the pediatric patient even when treatment with fresh frozen plasma has failed. Given its therapeutic potential, prospective, randomized trials are warranted.
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