Effect of substituting allogenic blood transfusion with autologous blood transfusion

Jan B. Wade · #1 (**permalink**) 12-01-2005, 03:20 PM

http://www.ncbi.nlm.nih.gov/entrez/q...455&query_hl=1

Ann Thorac Cardiovasc Surg. 2005 Oct;11(5):293-300.

Effect of substituting allogenic blood transfusion with autologous blood transfusion on outcomes after radical oesophagectomy for cancer.

Takemura M, Osugi H, Higashino M, Takada N, Lee S, Kinoshita H.

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

BACKGROUND: The oncologic benefit of avoiding allogenic blood transfusion in oesophageal cancer resection has not been studied. METHODS: The medical records of 68 patients (Auto group) who underwent a potentially curative oesophageal cancer resection without allogenic blood transfusion from 1996 to 1999 receiving 800 g of autologous blood donated preoperatively, and 97 patients (Allo group) who underwent the same operation with allogenic blood transfusion from 1990 to 1995 were compared. RESULTS: There were no differences in age, gender, stage of disease, number of retrieved nodes, or perioperative hemoglobin concentration between the two groups. The survival of the 45 patients with nodal involvement in the Auto group was better than that of the 59 patients in the Allo group (p=0.0435), and the survival of the 35 patients with T3 or T4 lesions in the Auto group was better than that of the 61 patients in the Allo group (p=0.0408). According to logistic regression analysis, allogenic blood transfusion correlated with tumour recurrence in patients with either nodal involvement or a T3-4 lesion. The natural killer cell activity remained higher in the Auto group than in the Allo group (p<0.05). CONCLUSION: Avoidance of allogenic blood transfusion favorably effected the survival of patients with oesophageal cancer at risk for recurrence.

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Effect of substituting allogenic blood transfusion with autologous blood transfusion

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