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The Anemia of Primary Autonomic Failure and its Reversal with Recombinant Erythropoie
Source:
Annals of Internal Medicine
Full Text Article Link (Free):
http://www.annals.org/cgi/content/full/121/3/181
The Anemia of Primary Autonomic Failure and its Reversal with Recombinant Erythropoietin
Results: Anemia was present in 32 of 84 patients (38%; 95% CI, 27% to 50%). Plasma norepinephrine levels, measured in patients standing upright, were lower in the patient group with lower hemoglobin levels. Mean values in 22 patients with a hemoglobin level of less than 120 g/L were as follows: hemoglobin, 108 g/L (range, 87 to 118 g/L); hematocrit, 0.33; corrected reticulocyte counts, 0.008; mean corpuscular volume, 89 fL (89 microns3); serum iron, 16.5 micromole/L (92 micrograms/dL); total iron binding capacity, 43.3 micromole/L (242 micrograms/dL); ferritin, 184 micrograms/L; serum vitamin B12, 410 pmol/L (556 pg/mL); and serum folate, 22.7 nmol/L (10 ng/mL). No relation was found between serum erythropoietin and blood hemoglobin levels. In seven of nine patients with autonomic failure who had hemoglobin levels less than 120 g/L, serum erythropoietin levels decreased below the 95% confidence interval corresponding to patients with iron deficiency anemia. Therapy with recombinant erythropoietin improved mean hemoglobin levels (from 108 to 133 g/L) in all patients treated (n = 5) at relatively low doses (25 to 50 units/kg body weight, subcutaneously, three times a week). Conclusions: Our data support the hypothesis that . . . http://www.annals.org/cgi/content/full/121/3/181
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