03-28-2005, 06:35 PM
|
|
Registered User
|
|
Join Date: Jan 2003
Posts: 1,438
Thanks: 7
Thanked 115 Times in 67 Posts
|
|
|
Association of ABO-mismatched platelet transfusions with morbidity/mortality
Transfusion. 2001 Jun;41(6):790-3
Association of ABO-mismatched platelet transfusions with morbidity and mortality in cardiac surgery.
Blumberg N, Heal JM, Hicks GL Jr, Risher WH.
Department of Pathology, University of ffice:smarttags" />Rochester Medical Center, lace w:st="on">Rochester, New York 14642, USAlace>. Neil_Blumberg@urmc.rochester.edu
BACKGROUND: The transfusion of ABO-mismatched platelets has been associated with increased morbidity and mortality during induction therapy for acute leukemia and allogeneic progenitor cell transplantation. STUDY DESIGN AND METHODS: Reported here is a cohort study of 153 patients undergoing primary coronary artery bypass graft or coronary valve replacement surgery by two surgeons in one institution during 1997 and 1998. All statistics employed nonparametric two-sided tests (Mann-Whitney; Fisher's exact test). RESULTS: Patients receiving at least one ABO-mismatched pool of platelets had a significantly longer hospital stay, more days of fever, greater total hospital charges, and more RBC transfusions. Mortality, hours in the intensive care unit, days on antibiotics, and numbers of platelet transfusions were also greater in recipients of ABO-mismatched platelets, but these differences were of less statistical significance. When the analysis was restricted to the 139 patients who received no more than two pools of platelets, the trends for increased morbidity and mortality (8.6% vs. 1.9%; p = 0.10) in recipients of ABO-mismatched platelets persisted. The number of RBC transfusions required in this latter cohort was 50 percent greater (mean, 6.1 vs. 9.2; p = 0.02), despite the fact that the number of platelet transfusions given was similar (mean, 1.2 vs. 1.3 pools; p = 0.22). CONCLUSIONS: ABO-mismatched platelet transfusions are associated with unfavorable outcomes in cardiac surgery, a relationship that remains unexplained. As this association has been found in three cohort studies in various clinical settings, further investigation of this association is warranted.ffice ffice" />>>
__________________
Mr. Jan B. Wade
Blood Management Consultant
Enhance Outcomes - Control Cost
For Information Call - 360 296-1807
Email
|
You are currently accessing this Site as a guest. Please login or register by clicking Here
Linear Mode
