03-05-2005, 12:21 PM
|
 |
Healthcare Professional
|
|
Join Date: May 1996
Posts: 1,472
Thanks: 22
Thanked 298 Times in 143 Posts
|
|
|
Comparative Effects of Red Blood Cell Transfusion and Increasing Blood Flow on Tissue
Am. J. Respir. Crit. Care Med., Volume 163, Number 7, June 2001, 1605-1608
Comparative Effects of Red Blood Cell Transfusion and Increasing Blood Flow on Tissue Oxygenation in Oxygen Supply-dependent Conditions
PHILIPPE VAN der LINDEN, STEFAN DE HERT, SYLVAIN BÉLISLE, FRANÇOISE DE GROOTE, NATHALIE MATHIEU, SANDRINE D'EUGENIO, VALÉRIE JULIEN, CHIWAN HUYNH, and CHRISTIAN MÉLOT
Department of Experimental Anesthesia, Erasme University Hospital, Brussels, Belgium Red blood cell (RBC) transfusion is usually administered to improve oxygen delivery (DO2) in order to sustain tissue oxygen demand. However, this practice is not supported by firm clinical or experimental data. Using a randomized two-period crossover design, this study compared the efficacy of "fresh" RBC transfusion and increased blood flow to restore tissue oxygenation in oxygen supply-dependent conditions. In 12 ketamine-anesthetized mongrel dogs submitted to nonpulsatile normothermic cardiopulmonary bypass, DO2 was reduced by a progressive decrease in pump flow. DO2 dependency was defined as an O2 uptake ( O2) decrease by more than 15% from baseline value. Then, intervention consisted of a 40% increase in DO2 obtained either by transfusion of "fresh" dog's RBC (stored < 3 d) or by increase in pump flow. Animals received both interventions sequentially in a random order, while O2 saturation was maintained constant. In O2 supply-dependent conditions, rising pump flow from 1.6 ± 0.4 to 2.7 ± 0.7 L/ min increased DO2 from 5.4 ± 1.1 to 9.0 ± 1.3 ml/kg/min (p < 0.01) and O2 from 3.5 ± 0.4 to 4.1 ± 0.5 ml/kg/min (p = 0.02). "Fresh" RBC transfusion, which increased the hemoglobin concentration from 6.4 ± 0.9 to 11.1 ± 1.3 g/dl, increased DO2 from 5.4 ± 1.2 to 9.0 ± 1.4 ml/kg/min (p < 0.01) and O2 from 3.6 ± 0.4 to 4.1 ± 0.5 ml/kg/min (p = 0.02). There was no difference in O2 resulting from both interventions. In oxygen supply-dependent conditions, "fresh" RBC transfusion and increased blood flow are equally effective in restoring tissue oxygenation.
__________________
Mr. Jan B. Wade
Blood Management Consultant
Enhance Outcomes - Control Cost
For Information Call - 360 296-1807
Email
|
noblood Home 
Linear Mode
Similar Threads
