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The Physiology of Oxygen Delivery
Introduction In order to survive humans have to be able to extract oxygen from the atmosphere and transport it to their cells where it is utilised for essential metabolic processes. Some cells can produce energy without oxygen (anaerobic metabolism) for a short time, although it is inefficient. Other organs (e.g.brain) are made up of cells that can only make the energy necessary for survival in the presence of a continual supply of oxygen (aerobic metabolism). Tissues differ in their ability to withstand anoxia (lack of oxygen). The brain and the heart are the most sensitive. Initially a lack of oxygen affects organ function but with time irreversible damage is done (within minutes in the case of the brain) and revival is impossible.
Full Article
http://www.nda.ox.ac.uk/wfsa/html/u10/u1003_01.htm
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