Results 1 to 2 of 2

Thread: Preoperative epoetin alfa vs autologous blood donation in primary total knee arthropl

  1. #1
    Registered User Sharon Grant's Avatar
    Join Date
    Dec 2003
    Location
    Los Angeles, California, United States
    Posts
    621

    Preoperative epoetin alfa vs autologous blood donation in primary total knee arthropl

    J Arthroplasty. 2006 Aug;21(5):628-35

    Preoperative epoetin alfa vs autologous blood donation in primary total knee arthroplasty. Department of Orthopedic Surgery, Kelsey-Seybold Clinic, Baylor College of Medicine, Houston, Texas 77025, USA.


    This prospective randomized trial compared preoperative autologous blood donation (PAD) with epoetin alfa in patients undergoing primary total knee reconstruction. Fifty adult patients with pretreatment hemoglobin level of 100 to 130 g/L were randomized to either epoetin alfa 40,000 U at preoperative days 14 and 7 or to a standard PAD protocol. Patient characteristics and operative blood loss were similar between groups. Baseline hematological parameters for epoetin alfa vs PAD were not significantly different; however, by the day of surgery the epoetin alfa group had significantly higher hemoglobin (130 vs 114 g/L; P < .001), hematocrit (0.408 vs 0.352; P < .001), and reticulocyte count (3.4 vs 2.1 x 10(9) cells per liter; P < .001). These differences remained significant for 1 to 2 days postoperatively. There was no significant difference in the incidence of allogeneic transfusions between groups (28% for epoetin alfa vs 8% for PAD; P = .1383). Both treatments were generally well tolerated. Epoetin alfa appears to be a safe alternative to PAD in patients who are at risk for transfusion in the perioperative period following total knee arthroplasty.



    Entrez PubMed
    Sharon Grant
    Editorial Team

  2. New Feature! NoBlood Answers!

    • ASK questions regarding Transfusion Alternatives and Patient Blood Management.
    • SHARE your facts, opinions and personal experience.
    • DISCOVER the best answers chosen by Healthcare Professionals and the Public.
    • RANK the best answers.

    Click here to see the Best Answers to Top Questions.

  3. #2
    Registered User
    Join Date
    Jul 2008
    Posts
    18
    Thank you for this current information.

Similar Threads

  1. Preoperative epoetin alfa vs autologous blood donation in primary total knee arthropl
    By Sharon Grant in forum Medical Articles and Abstracts
    Replies: 2
    Last Post: 03-19-2009, 11:55 PM
  2. Preoperative administration of epoetin alfa to reduce transfusion requirements in TJ
    By Jan B. Wade in forum Medical Articles and Abstracts
    Replies: 1
    Last Post: 10-30-2008, 04:26 AM
  3. Replies: 0
    Last Post: 06-15-2007, 11:22 PM
  4. Replies: 0
    Last Post: 04-05-2005, 12:23 AM
  5. Are tourniquets and drains really required in primary total knee?
    By Jan B. Wade in forum Medical Articles and Abstracts
    Replies: 0
    Last Post: 10-31-2003, 12:20 PM

Tags for this Thread

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •