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This is a discussion on Dic within the Ask a Professional forum; My critical care instructor mentioned last week that she has seen about 6 patients in ...
noblood Home
11-05-2007, 09:49 AM
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Dic
My critical care instructor mentioned last week that she has seen about 6 patients in 20 years (around) experience with DIC. All those patients recieved transfusions, wide open. None survived. Has anyone ever seen/had a pt. that has survived with use of non-blood products? I know the prognosis is very grim... just wondering! THanks!
    
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11-05-2007, 11:41 PM
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A new development is drotrecogin alfa (Xigris), a recombinant activated protein C product. This deactivates clotting factors V and VIII and the presumed mechanism of action of drotrecogin is the intravascular coagulation. Expensive and used mostly in ICU's.
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Jim Laws
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11-08-2007, 11:49 AM
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Most hospitals have a protocol for controlling major hemorrhage, summarized by an algorithm or flow chart outlining what steps to take in such an emergency. The chief of anesthesiology at the teaching hospital I am associated with told me that in the case of Jehovah's Witnesses with major obstetric hemorrhage, his department and the obstetricians bypass all of the other steps and go straight to the last one: "If bleeding continues uncontrolled, consider antifibrinolytic or recombinant factor VIIa." Recombinant factor VIIa almost invariably either stops the bleeding or slows it to a manageable rate within minutes. The literature reports that Factor VIIa can be very effective in controlling DIC. Clinicians need to be educated to adopt this strategy in patients who cannot accept blood transfusion.
(See the post: Hemorrhage from DIC controlled by Factor VIIa)
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