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Old 05-12-2005, 12:14 PM
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warrenbehr is on a distinguished road
Factor V Deficiency

Does anyone have any experience with this disorder? We have a family of Jehovah's Witnesses asking for advice on bloodless treatment options in case of trauma. All the web-based information seems to point only to fresh plasma or fresh frozen plasma infusions as treatment to "correct the deficiency temporarily and should be given daily during a bleeding episode."

Any information would be greatly appreciated!

Quote:
What Is It?
Factor V deficiency is also known as Owren's disease or parahemophilia. This deficit was identified in Norway in 1943. Since then about 150 cases have been reported, occurring in both men and women. The exact frequency of this rare disorder is unknown, but is estimated to be one per 1 million.

The role of factor V is to accelerate the activity of thrombin. When levels of factor V are low, blood clotting is delayed or it progresses slowly. People with this deficiency may have occasional nosebleeds, excessive menstrual bleeding and bruising; although, many have no symptoms. The first sign of this condition may be bleeding following surgery.

In this disorder, bleeding ranges from mild to severe. The disease is similar to hemophilia, except that bleeding into joints is uncommon. Bleeding can occur almost anywhere in the body, and death from hemorrhage has occurred with this disorder. Excessive bleeding with menstrual periods and postpartum hemorrhage occurs frequently.

A family history of a bleeding disorder is a risk factor. Men and women are affected equally.
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