I spoke to someone at Jehovah Witness' who indicated that their group, based upon biblical beliefs, holds that humans should not recieve whole blood or any of its four primary components: red blood cells, white blood cells, plasma, platelets. They indicated that while they would not officially endorse a product such as Polyheme, it would be up to the individual to make their own decision since PolyHeme is derived by extracting hemoglobin from RBCs, and then processing it several times.